Zenith Suspension Dosage/Direction for Use

Adults: In uncomplicated Chlamydia trachomatis urethritis and cervicitis the dosage is 1000 mg as a single oral dose.
For all other indications the dosage is 1500 mg, to be administered as 500 mg per day for three consecutive days. Alternatively the same total dosage (1500 mg) can also be given over a period of 5 days with 500 mg on the first day and then 250 mg on days 2  to 5.
Elderly: In the elderly the same dosage as for adults can be given.
Children and adolescents (<18 years): The total dosage in children aged 1 year and older is 30 mg/kg administered as 10 mg/kg once daily for three days, or over a period of five days starting with a single dose of 10 mg/kg on the first day, followed by doses of 5 mg/kg per day for the following 4 days, according to the tables shown as follows. There is limited data on use in children younger than 1 year.
Azithromycin monohydrate (Zenith) 200 mg/5 ml powder for oral suspension: See Table 2.

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The dosage for the treatment of pharyngitis caused by Streptococcus pyogenes is an exception: in the treatment of pharyngitis caused by Streptococcus pyogenes Azithromycin monohydrate (Zenith) has proved to be effective when it is administered to children as a single dose of 10 mg/kg or 20 mg/kg for 3 days with a maximum daily dosage of 500 mg. At these two dosages a comparable clinical effect was observed, even if the eradication of the bacteria was more significant at a daily dosage of 20 mg/kg.
Penicillin is however the drug of first choice in the treatment of pharyngitis caused by Streptococcus pyogenes and the prevention of subsequent rheumatic fever.
Patients with renal insufficiency: In patients with mild to moderate renal insufficiency (creatinine clearance > 40 mL/min) adjustment of the dosage is not necessary. For patients with more serious renal insufficiency: see Precautions.
Patients with hepatic insufficiency: See Precautions.
Method of administration: Before use, the powder should be reconstituted with water: see preparation of the suspension. After reconstitution the drug can be administered using a PE/PP syringe for oral use.
After taking the suspension a bitter after-taste can be avoided by drinking fruit juice directly after swallowing. Azithromycin monohydrate (Zenith) powder for oral suspension should be given in a single daily dosage. The suspension can be taken together with food.